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From a biological standpoint, TfR1 by also binding hemeHPX acts as a scavenger receptor recognizing an array of structurally diverse endogenous proteins, some with key roles in maintaining the cell and whole-body homeostasis of both heme and its iron

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4430-A PI3K/AKT SIGNALING ON IMMUNE ESCAPE AND IMMUNE INFILTRATION IN HCC RECURRENCE Chong Wa To 1 , Soumita Ghosh 1 , Xun Zhao 1 , Elisa Pasini 2 , Sandra Elisabeth Fischer 3 , Elmar Jckel 2 , Anand Ghanekar 4 , Gonzalo Sapisochin 1 and Mamatha Bhat 1 , (1)University Health Network, (2)Ajmera Transplant Center, University of Toronto, Toronto, ON, Canada, (3)University of Toronto, (4)The Hospital for Sick Children Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease with complex mechanistic pathogenesis, which contributes to aggressive HCC recurrence