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MDD has a lifetime prevalence of 12% and is a leading cause of global disability (Filatova et al

Berger J, Moller DE

Various anatomical barriers, including the cornea, tear film, and blinking initially limit intraocular accumulation in the anterior segment [15, 16]

24 Three standard deviations above this mean, corresponding to 10% of mean normal activity, was taken as the threshold below which individuals were considered to have profound biotinidase deficiency