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Lo que NO sabemos Magnitud exacta del riesgo con administracin exgena de LR3 vs IGF-1 endgena alta Umbral de exposicin que produce seal clnicamente relevante Reversibilidad del riesgo si se suspende el compuesto Interaccin con otros factores (gentica BRCA, edad, historia familiar oncolgica) La cautela metodolgica es razonable: limitar exposicin acumulada, monitorear biomarcadores oncolgicos relevantes (PSA en hombres, exmenes especficos segn historia familiar), considerar la exposicin como riesgo cuantificable, no negligible

Another important reason for limiting the utilization of EGCG when taken orally is the low absorption efficiency, most of which does not enter the blood but enters the excretory system through bile and is excreted by feces [22]

Relative to CD-fed recipients, HFD-fed recipients with WT lesions showed a tendency for lower lesion incidence and significantly lower lesion numbers