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Liu and Aghajanian, 2008), the somatosensory cortex (Jeanneteau et al., 2018), the motor cortex (Liston and Gan, 2011), hippocampus (Patel et al., 2018), amygdala (Patel et al., 2018) and striatum (Dias-Ferreira et al., 2009)

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Several TRK inhibitors, including Entrectinib [20], Larotrectinib [21] or Repotrectinib [22, 23], have shown impressive responses in cancers with rearranged NTRK, including lung, colorectal, thyroid, neuroblastoma, gastric carcinoma, and pediatric cancers