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DNMT1-mediated mitochondrial function regulation is also involved in myocardial I/R injury following heart transplantation, where DNMT1 mediates hypermethylation of the microsomal glutathione S-transferase 1 ( MGST1 ) gene promoter, leading to its significant downregulation

Neurological symptoms associated with B12 deficiencysuch as paraesthesia, ataxia, or cognitive impairmentrequire urgent treatment with more frequent injections (1mg on alternate days initially) to prevent irreversible nerve damage

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As an example, lets look at Konya, Turkey, and compare it with other places