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M.SakoD.MitchellD.LiR.et al (2014a)

Oxidative stress and ROS amplification Oxidative stress is a hallmark of ARDS and plays a pivotal role in driving ferroptosis

Figure 3 (b) Glycolysis pathway, demonstrating niacins (B3) role in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, and its links to both the Pentose Phosphate Pathway and the Krebs Cycle ( (c) Krebs Cycle, illustrating its connection to glycolysis, Electron Transport Chain, and Fatty Acid Beta-Oxidation pathway

In both humans and mice with NASH, the serum levels of A1AT were significantly decreased, whereas those of proteinase 3 (PR3), a pro-inflammatory serine protease, were increased