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Supplements must be paired with aggressive pacing strategies to avoid post-exertional malaise (PEM), nervous system regulation techniques, and ongoing medical care from practitioners who truly understand the nuances of complex chronic illness

Overuse may cause mild irritation or temporary purging

In AHFIRM subjects there was wide variability in alcohol consumption as measured by PEth

169,177,178 In a preliminary trial in 17 healthy reproductive-aged women, taking 4,000 mg of an omega-3 fatty acid supplement (providing 1,860 mg eicosapentaenoic acid [EPA] and 1,500 mg docosahexaenoic acid [DHA]) daily for one month led to reductions in levels of FSH, a hormonal marker of diminished ovarian reserve and early menopause, in normal weight, but not obese, participants