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Description

Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia

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Prep Your Supplies: Wash hands and gather the B12 cyanocobalamin vial, insulin syringe, alcohol swabs, and a sharps container

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It is caused by mutations in the NF1 tumor suppressor gene, which encodes a GTPase activating protein (GAP) that negatively regulates p21-RAS signaling

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