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Even the approved 4g/day dose for two weeks can raise liver enzyme levels in about a third of patients

One per compound HPLC Chromatogram and one per compound Mass Spectrometry Confirmation

PMID 34225578 El-Mancy EM, Elsherbini DMA, Al-Serwi RH, El-Sherbiny M, Ahmed Shaker G, Abdel-Moneim AH et al (2022) -Lipoic acid protects against cyclosporine A-induced hepatic toxicity in rats: effect on oxidative stress, inflammation, and apoptosis

Proc Natl Acad Sci USA 111: 1664716653 Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, Sullivan SA, Nichols AG, Rathmell JC (2011) Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets