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Calvert S, Tacutu R, Sharifi S, Teixeira R, Ghosh P, de Magalhes JP

Loss-of-function TNSALP mutations lead to ineffective PLP dephosphorylation to pyridoxal, reduced pyridoxal transfer into the brain, and accumulation of PLP in blood ( Several proteins are involved in the formation of GPI anchors that tether extracellular tissue non-specific alkaline phosphatase to the cell membrane

GST M2-2 is a prostaglandin E synthase in the brain cortex [8] and rat GST A1-1 and GST A3-3 catalyze the reduction of PGH 2 to PGF 2

Treatment with BSO decreased significantly the GSH level at 24 h of culture, which augmented towards 72 h, but the levels persisted significantly lower than control