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Mechanistically, the inflammatory response after heart transplantation is mediated by TLR4/TRIF signaling pathway, which facilitates neutrophil migration to coronary endothelial cells, resulting in ferroptosis in the transplant endothelial cells

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doi: 10.1016/j.bbadis.2014.10.016 Summary Keywords sirtuin 1, natural compounds, oxidative stress, human disorders, polyphenols Citation Iside C, Scafuro M, Nebbioso A and Altucci L (2020) SIRT1 Activation by Natural Phytochemicals: An Overview