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A comprehensive investigation into the mechanisms of cardiomyocyte death will facilitate a thorough understanding of the pathological processes underlying PO-HCM, which is essential for early diagnosis and effective treatment

We introduced Dox-inducible FL Flag-tagged p21, or isolated N and C terminal truncation mutants (p21 N and p21 C , respectively), into HT-1080 p21 KO cells (Tarangelo et al, 2018)

When HK-2 cells were treated with MLN4924, the UBE2m overexpression-induced increase in neddylation and expression of NEDD4 was rescued, as was the decrease in PPAR expression induced by NEDD4 elevation (Fig

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