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Description

Metabolic routes in inflammation: the citrate pathway and its potential as therapeutic target

Older diagnostic criteria, including the simplified scoring system, primarily focused on portal-based inflammation characteristic of chronic AIH but did not adequately account for histological changes seen in acute AIH presentations, leading to misclassification or underdiagnosis

In amphetamine-induced mania animal models, pharmacologic antagonism or genetic deletion of P2X7 appears to be behaviorally therapeutic, with concomitant reductions in proinflammatory cytokine release and lipid peroxidation [1]