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NNMT catalyzes a reaction where it takes methyl groups from the bodys universal methyl donor (SAM) and transfers them onto vitamin B3, producing what is essentially a metabolic dead end

Research potential persists: Despite clinical failure, AOD-9604 remains useful as a laboratory model for studying growth-hormone fragment signaling, adipocyte biochemistry, and peptide-receptor interactions

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When researchers tested AOD-9604 in mice with knocked-out beta-3 receptors, it still increased energy expenditure and fat burning through alternate mechanisms