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In the context of obesity research, Adipotide has demonstrated the ability to cause rapid, significant weight loss in rhesus monkeys and rodents by literally destroying the tissue structure of fat deposits

Ultracentrifugation, tangential flow filtration, and size-exclusion chromatography are some of the techniques that have helped in making these processes more clinical for scalability [29]

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These experiments demonstrated that the relatively low dose of MK-801, required for achieving a synergistic weight loss by the conjugate, does not affect the body temperature after 14 days of repeated dosing, as none of the treatment groups displayed different core temperature compared with the vehicle-treated mice (Extended Data Fig