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Analyses of biochemical parameters, including the levels of liver enzymes in the serum (ALT, AST), indicated significant damage to the livers of mice receiving D-galactose, with D-galactose inducing oxidative stress through an increase in lipid peroxidation (MDA) and decreases in the glutathione contents in brain and liver tissues

CCK and ANA assisted in editing data extraction tables

Critically, whereas ML210 and JKE-1674 cannot react covalently with purified GPX4, JKE-1777 can react with purified GPX4 and yields the same 434 Da adduct that other ML210-derived analogs generate with GPX4 only in cells (Figure 6C)

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