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Finally, the FOT values were calculated for all samples and used in all subsequent quantitative analyses to correct sample loading differences

Given the rich lipid content of the nervous system, hemoglobin-derived iron works with lipid peroxidation to induce ferroptosis, which eventually leads to neuronal mitochondrial damage, edema, and apoptosis of neurons and astrocytes

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Most adverse effects were encountered during individualized titration and resolved by slowing the rate of increase to full dose or lowering the dosage (see dosage section) of the supplement/placebo