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Signs and symptoms of toxicity (1, 5) Garlic odor in the breath Metallic taste in the mouth Hair and nail loss or brittleness Lesions and rashes on the skin Nausea Diarrhea Mottled teeth Fatigue Irritability Nervous system abnormalities Acute selenium toxicity in humans is rare, but intentional or accidental ingestion of large amounts of selenium can be fatal

10.1007/978-3-319-20164-1_1 156 DunkerA

Since H3K18la affects DNA transcriptional activity by enriching at the promoters of target genes, such as the oncogene c-Myc (20), this lactylation modification consequently confers therapy resistance by activating survival-related genes, including glutamate-cysteine ligase catalytic subunit (52)

Histrelin is an even more potent GnRH analogue than deslorelin, but with similar clinical efficacy in inducing ovulation in horses as deslorelin or hCG