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The normal range for piperine is reported to range from 2%7.4% in black pepper ( TABLE 4 Piperine content, total phenolics, and antioxidant activity of untreated and 60 min HPV treated whole black peppercorn

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Although the secretory pathway promotes oxidative folding through the oxidoreductase family, a large proportion of glutathione in the ER lumen is found as mixed disulphides with proteins (Bass et al , 2004)