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T cell receptors (TCRs) provide a recognition signal for T cells complemented by a co-stimulatory signal that can provide an on/off signal to regulate the activation of T cells

For instance, engineered heart tissues exposed to prolonged afterload or continuous neurohormonal stimulation, such as norepinephrine or transforming growth factor- (TGF-), exhibit progressive contractile decline, prolonged calcium transients, and arrhythmic bursts, which are characteristic of heart failure and maladaptive remodeling

To facilitate comparison across tumor types, we summarized representative DTP-associated molecular markers and transcriptional signatures across major cancer contexts ( Table 2 )

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