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In addition, several of these proteins appear to be localized in the endoplasmic reticulum (41), thereby suggesting roles in protein folding or regulation of protein degradation

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However, this research is subject to certain limitations

Indeed, it is known that Nrf2 is a master factor for the regulation of antioxidant response elements (ARE) in several antioxidant and phase II detoxifying proteins in different cell types, including nerve cells (Kobayashi and Yamamoto, 2013), and several reports have shown that although DHA itself does not bind Nrf2, it may stimulate transcriptional activity of ARE-containing genes through activation of Nrf2 upon generation of 4-hydroxy-2-hexenal, which indeed activates Nrf2 (Ishikado et al., 2013)