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Daver N, Assi R, Garcia-Manero G, Ravandi, Borthakur G, Jabbour E, DiNardo CD, Kadia TM, Ning J, Nogueras-Gonzalez G, Pierce S, Kelly M, Zhang W, Gombos DS, Kornblau S, Konopleva M, Cortes J, Kantarjian H, Andreeff M

Side Effects and Safety Side effects Across preclinical studies and the small human trials published to date (~28 subjects across pilot studies), the reported adverse events stay limited: Mild injection-site irritation (rare) No systemic toxicity at therapeutic doses in published reports Oral administration: mild GI upset in sensitive individuals No immunosuppression, hormonal disruption, or metabolic side effects have been observed