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6 Targeting ferroptosis for the prevention and treatment of neurodegenerative diseases: strategies and future perspectives Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical mechanism in the pathogenesis of various neurodegenerative diseases and aging-related disorders (404408)

This superoxide is rapidly converted into hydrogen peroxide (HO), which, in the presence of Fe 2+ , generates highly reactive hydroxyl radicals (OH) through the Fenton reaction