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doi: 10.3389/fphar.2014.00192 Received 13 June 2014 Accepted 26 July 2014 Published 20 August 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Rahman M

Interleukin-1beta biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice

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Second, toxic gain-of-function mechanisms from abnormal -synuclein aggregate accumulation cause axonal transport impairment [228, 229] and inhibition of protein degradation systems, including the lysosomal-autophagy [230, 231] and ubiquitin-proteasome pathways [232, 233]