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The resulting no-reflow phenomenonwherein tissue perfusion remains inadequate despite macrovascular restorationexacerbates hypoxia and creates a self-amplifying cycle of inflammation, mitochondrial damage, and microcirculatory failure (95)

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The hippocampus displays microglial activation, elevated IL-6 and tumor necrosis factor alpha (TNF-), as well as neurotrophic factor signaling disturbances in APP1/PS1 mice with anxiety-like phenotypes (Gao et al., 2018)