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Price: 29.18 USD
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Rating: 4.846 (6 reviews)

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In addition, itaconate was investigated for its role as an anti-inflammatory and antioxidant metabolite of the TCA cycle [124]

10.1055/s-0028-1088314 [DOI] [PubMed] [Google Scholar] Seelinger G., Merfort I., Wlfle U., Schempp C

Ji DX, Yamashiro LH, Chen KJ, Mukaida N, Kramnik I, Darwin KH, Vance RE

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019