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2A, the treated cells presented smaller mitochondria, a higher density of the mitochondrial membrane, and reduced mitochondrial cristae

Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, Gu M, Bullock AJ, Chang DT, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar MD, Wollison BM, Khalaf N, Perez K, Syngal S, Aguirre AJ, Hahn WC, Meyerson ML, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC , Nowak JA, Wolpin BM

Likewise, caffeic acid itself directly inhibited ERK1/2 (MAPK) activity in melanoma and epidermoid carcinoma cells, disrupting a key pathway that promotes tumor growth and migration (150)