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Rights and permissions Copyright information 2014 Springer-Verlag London About this chapter Cite this chapter Burcham, P.C

The dysfunctional glutamine metabolism leads to the excessive proliferation/migration of vascular cells via multiple mechanisms akin to that in tumor cells

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However, in other rodents or mammals, selenocysteine cannot be synthesized due to the lack of selenocysteine insertion sequences in related genes, and it is a non-selenium protein replaced by cysteine (Cys) (Brigelius-Floh and Maiorino, 2013)