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Instead of accurately interpreting sensory input, pain-processing circuits become hyperresponsiveturning normal movement, pressure, or minor inflammation into persistent pain

(C): Photomicrograph of T.S in the liver of Tadalafil group treated rats showing: Loss of the normal hepatocytic architecture, vacuoles, degeneration of hepatocytes with pyknotic nuclei (black square& black arrow), fibrosis and congestion around the portal area and (black circle), dilation and congestion of portal vein (blue dotted arrow), congestion in hepatocytes and blood sinusoids (black dotted arrow), binucleated hepatocyte (green dotted arrow)

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Spinal cord injury target-immunotherapy with TNF- autoregulated and feedback-controlled human umbilical cord mesenchymal stem cell derived exosomes remodelled by CRISPR/Cas9 plasmid