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A procedure called Kasai hepatoportoenterostomy (KPE) that replaces the obliterated extrahepatic bile duct with an intestinal conduit is the first-line treatment to re-establish the bile flow with only 50% success rate ( BA is most likely a clinical phenotype resulting from a number of prenatal or perinatal insults to the hepatobiliary tree, and this disease is underpinned by a number of key pathobiological factors (KPFs) either singly or more often in combinations

The excess accumulation of ROS in degenerative IVD would cleave the boronic ester bonds of PG@MBC dynamic hydrogel to trigger the release of MBC nanozyme in a ROS-responsive pattern, which facilitates targeted uptake by NPCs through a high-affinity homologous membrane interaction

Biophysical studies examine how dynamic movements impact joint mechanics and ligament stress, helping to design exercises that improve functional performance while minimizing the risk of re-injury