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10.1038/nrurol.2015.301 Nat Rev Urol

Various chronic, age-related diseases such as those related to neurodegeneration, mitochondrial dysfunction, and even cancer, have been related to suboptimal or deficient glutathione levels, confirms a Nutrients review

Moreover, multiple studies in Gram-negative bacteria have shown that the ArcAB two-component signal transduction system, which normally acts as a global regulator of anaerobic growth of bacteria, also plays a role in the resistance to ROS and supports bacterial survival under oxidative stress conditions [273,274,275]