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However, only two pH values were evaluated, so no specific conclusion could be drawn from those studies [25]

Equol producers exhibited weight growth, while nonproducers experienced decreased blood pressure

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The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events