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Approaches to the diagnosis and management of patients with a history of nonsteroidal anti-inflammatory drug-related urticaria and angioedema

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The photoprotection mechanism in the black-brown pigment eumelanin

Using PDE5 radiotracers with optimal pharmacokinetic profiles in combination with high accuracy would likely address multiple issues facing clinical investigators, such as (i) providing valuable diagnostic information regarding the localization, extent and severity of impairments and/or deregulation of the cGMP/PDE5 pathway, thus permitting an early identification of patients that would benefit from treatment with PDE5-Is, (ii) quantification of changes in PDE5 expression during disease progression, and (iii) assessment of occupancy by PDE5-Is in target tissues enabling physicians to tailor optimal dose and dosage regimens on an individual basis [274,275,276]