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Extending the application of natural transporters, another research group also investigated the synthetic LDL-nanodiscs (structural analog of HDL) for targeting low-density lipoprotein receptors (LDLRs) on glioma cells to increase specificity and accumulation of glioma cells

They discovered that administrating PHRO injection via tail venous could effectively penetrate the BBB, resulting in the sustained release of Rg1, which ultimately decreased the volume of cerebral infarction and enhanced recovery of neurons in rats suffering diabetes and cerebral infarction (Shen et al., 2017