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It is worth noting that while this hAOX metabolism was observed in this study, the half-lives of the compounds screened in human liver cytosol were high (90 minutes), and therefore further work is needed to establish the relevance of hAOX metabolism in the overall clearance of PROTAC molecules

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BMC Med Ethics 24:83 [DOI] [PMC free article] [PubMed] [Google Scholar] 163.Samuel G, Hardcastle F, Broekstra R, Lucassen A (2022) Exploring how biobanks communicate the possibility of commercial access and its associated benefits and risks in participant documents