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The second study was the previously discussed WES and RNA-seq analysis of 160 tumour and matched non-malignant tissue samples from never-smoking patients with LUAD, with a substantially higher percentage of East Asian patients (62% European and 25% East Asian by inferred genetic ancestry), and including 40 and 36 samples from The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumour Analysis Consortium cohorts, respectively 7

When the intestinal barrier becomes compromiseda condition known as leaky gut toxins, microbes, and food particles can escape into the bloodstream, triggering systemic inflammation, autoimmune reactions, and chronic disease