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There are several other NE inhibitors in different stages of clinical trials including alvelestat (AZD9668, COPD, phase 2, US national clinical trial number NCT03636347) (Stockley et al., 2013), BAY 85-8501 (noncystic fibrosis bronchiectasis, phase 2, NCT01818544), (Watz et al., 2019), lonodelestat (POL6014, cystic fibrosis, phase 1, NCT03748199) (Barth et al., 2020), CHF6333 (noncystic fibrosis bronchiectasis, phase 1, NCT03056326, NCT04010799) (Gramegna et al., 2017), and elafin (ARDS, phase 1, NCT02944279) (Barnes et al., 2020)

LC-MS data were analyzed by El-Maven software 87 , and compounds were identified by matching to LC-MS method specific retention time values of external standards

Exploring the mechanism of senna glycoside A in the treatment of diabetic nephropathy based on the Nrf2/HMOX-1 iron death signalling pathway

, Fibroblasts also import cystine through the cystine/glutamate transporter and reduce it to cysteine, maintaining the pericellular environment in a reducing state in vitro