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Additionally, IS accumulates in the skeletal muscle of patients with CKD, potentially leading to mitochondrial dysfunction in muscle cells

Abbreviations 4-HNE: 4-Hydroxy-2-nonenal AIF: Apoptosis-inducing factor AKAP-121: A-kinase anchoring protein 121 Akt/PKB: Protein kinase B AMI: Acute myocardial infarction AMPK: AMP-activated protein kinase ANT1: Adenine nucleotide translocator 1 CaMKII: Ca 2 + /calmodulin-dependent protein kinase II CCR2: CC chemokine receptor type 2 cGMP: Cyclic guanosine monophosphate circRNA: Circular ribonucleic acid DOCA: Deoxycorticosterone acetate Dok-4: Docking protein 4 EMPA: Empagliflozin ERK1/2,: Extracellular signal-regulated kinase 1/2 EVs: Extracellular vesicles Fer-1: Ferrostatin-1 gp130: Glycoprotein 130 GPCR: G-protein coupled receptor GSH: Glutathione GSK-3: Glycogen synthase kinase-3beta HSPA12B: Heat shock protein A12B IL-6: Interleukin-6 IL-37: Interleukin-37 lncRNA: Long non-coding RNAs IPC: Ischemic preconditioning IRI: Ischemia/reperfusion injury JAK: Janus kinase JNK: C-Jun N-terminal kinase Lck: Lymphocyte-specific protein tyrosine kinase MACE: Major adverse cardiovascular events MEK: Mitogen-activated protein kinase kinase MEKK1: Mitogen-activated protein kinase kinase kinase 1 Mfn1: Mitofusin-1 Mfn2: Mitofusin-2 MIF: Macrophage migration inhibitory factor MLKL: Mixed lineage kinase domain-like protein mPTP: Mitochondrial permeability transition pore mtDNA: Mitochondrial DNA NAC: N -Acetylcysteine ncRNAs: Non-coding RNAs NGF: Nerve growth factor NLRP3: NLR family pyrin domain containing 3 protein NO: Nitric oxide NPs: Natriuretic peptides Nrf2: Nuclear factor erythroid 2-related factor 2 p38: P38 mitogen-activated protein kinase PAR: Poly(ADP-ribose) PARP-1: Poly (ADP-ribosome) polymerase 1 PDE5: Phosphodiesterase type 5 pGC: Particulate guanylate cyclase PI3K: Phosphatidylinositol-3-kinase PINK1: PTEN-induced putative kinase 1 Pitx2: Pituitary homeobox 2 PKC-: Protein kinase C epsilon PKG: Protein kinase G PostC: Ischemic postconditioning PRRs: Pattern recognition receptors PTEN: Phosphatase and tensin homolog RIC: Remote ischemic conditioning RIPK1: Receptor-interacting protein kinase 1 RIPK3: Receptor-interacting protein kinase 3 RISK: Reperfusion injury salvage kinase SAFE: Survivor activating factor enhancement SFKs: Src-family kinases sGC: Soluble guanylyl cyclase SR: Sarcoplasmic reticulum Src: Proto-oncogene tyrosine-protein kinase SSO 2 : Supersaturated oxygen STAT3: Signal transducer and activator of transcription 3 TAZ: Tafazzin TEAD4: TEA domain transcription factor 4 TLR4: Toll-like receptor 4 TNF-: Tumor necrosis factor TNF-R: Tumor necrosis factor receptor VDAC: Voltage-dependent anion channel YAP: Yes-associated protein References Abe J, Yamada Y, Takeda A, Harashima H (2018) Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium

10.1016/S0006-3223(98)00141-3 39

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