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Yes, weight loss plateaus occur in 30-40% of patients by month six due to receptor desensitization and metabolic adaptation

The increased delivery of BAs to the distal L cells and the altered GPBAR1 receptor activation, however, do not seem to play a master role in the early increases in the intestinal secretion of GLP1 and PYY, as seen after other procedures of bariatric surgery (156163)

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