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K.DumotJ.FaulxA.et al (2018)

Key benefits associated with optimal glutathione levels include: Enhanced Detoxification: Supports the liver in processing and eliminating harmful substances from the body

One explanation is compartmentalized immunity: emerging data suggest that spinal enthesitis may generate IL-17 via IL-23-independent routes (e.g., local innate immune cells responding to mechanical stress)[40], whereas peripheral enthesitis and gut lesions do depend on IL-23[41], indicating a potential divergence in cytokine dependency across tissues[42]