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10.3969/j.issn.1006-9690.2024.06.003 50 JiaH.ZhaoZ.SuC.DuJ.YangS.SongJ.et al (2025)

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The Role of APOE4 in Aggregation of Amyloid-Beta Peptides There are two pathological hallmarks in the pathogenesis of AD: (i) the formation of extracellular amyloid plaques in the brain and (ii) the formation of intracellular neurofibrillary tangles in neurons (Hardy and Selkoe 2002)