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Nonetheless, the introduction of LY294002 substantially eliminated CAs pro-osteogenic effects

Studies have shown that heavy metal contamination in soil can lead to various physiological and biochemical alterations in guar plants, including the inhibition of seed germination, decline of plant growth, impairment of photosynthesis, disruption of nutrient uptake, and inducing oxidative stress [18, 19]

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The authors have shown that CBD increases the expression of selected proteins involved in upregulating lipid metabolism, i.e., catalytic subunit of 5AMP-activated protein kinase (AMPKa2), extracellular signal-regulated kinase (ERK1/2) along with signal transducers and transcription activators (STATs) in hepatocytes (Figure 2, Table 1) (36)