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Smith-Magenis syndrome (a congenital disorder due to a haplo-insufficiency of the retinoic acid-induced 1 gene, involved in the regulation of the expression of circadian genes) patients present with an inverted rhythmic melatonin secretion and sleep difficulties that can be managed with melatonin administration in the evening and -adrenergic blockers during the day to reduce melatonin secretion (82)

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Gonzlez-Guerra JL, Castilla-Cortazar I, Aguirre GA, Muoz U, Martn-Estal I, vila-Gallego E, Granado M, Puche JE, Garca-Villaln A (2017a) The sole partial insulin-like growth factor (IGF-1) deficiency reduces heart contractibility, angiotensin II sensibility, and alters gene expression of structural and functional cardiac proteins Gonzlez-Guerra JL, Castilla-Cortazar I, Aguirre GA et al (2017b) Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins