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The volcano plots showed the Sham group compared with those of the 6 h group (A) , 36 h group (B) , 72 h group (C) , and 168 h group (D)

doi: 10.1016/j.str.2014.09.009 146 SasakiTShiraiTTsukijiNOtakeSTamuraSIchikawaJet al

Other less common causes of increased iron stores include gestational alloimmune liver disease (GALD), increased intake due to an iron-loaded diet such as in African iron overload and excessive use of iron supplements or therapeutic infusions of iron-containing products such as hemin, used to treat certain porphyrias

Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via nrf2/slc7a11/gpx4 signaling pathway