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Key pathogenic factors include: Hormonal influences (e.g., oestrogen/progesterone) up-regulating melanocyte tyrosinase activity

People with other chronic pain conditions such as headaches, back pain, arthritis, and other rheumatologic diseases have an increased risk of fibromyalgia

GSH-enhanced T cells can produce more infection-fighting substances like interleukins-2 and -12 (IL-2, IL-12) and interferon-gamma, working to control both bacterial and viral infections in this way.16 In particular, one study found that GSH doubled NK cell's ability to be cytotoxic (kill invaders) after just six months of use.17 It also appears that glutathione has a direct antibacterial effect even as it helps macrophagesa cell of the immune systemfight the bacterium that causes tuberculosis (Mycobacterium tuberculosis).18 In this study, researchers found that "GSH works to modulate the behavior of many cells including the cells of the immune system, augmenting the innate and the adaptive immunity as well as conferring protection against microbial, viral and parasitic infections." 18 Many chronic infections suck as EBV, Hepatitis, Herpes Viruses, and Lyme, to name a few, which can deregulate and suppress the immune system

Interestingly, although carriers of the ApoE 4 genotype exhibit reduced CSF ApoE levels, no significant association was found between ApoE 4 and CEC [13]