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Contradictory findings from these studies could be likely explained, at least partly, by small sample sizes (and, consequently, by limited statistical power to detect associations) and also by narrow age ranges investigated (Der et al., In many studies, TL was examined as a single measure of aging rate

258 Reduced glucose metabolism often precedes clinical AD symptoms, initially affecting the parietal-temporal lobes and posterior cingulate cortex before spreading to other regions, such as the frontal lobes

Appointments are at Manchester Chemist, Unit 11, 20 to 22 Mary Street, Cheetham Hill, Manchester, M3 1DZ