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Drugs within a group have similar R1-side chains and display cross-allergic reactions (whereas drugs in different groups are not cross-allergic): Penicillin, aminopenicillins & selected G1-G2 cephalosporins Cefazolin Nafcillin Piperacillin-tazobactam Cefepime & most G3 cephalosporins Ceftazidime & aztreonam Ceftaroline Carbapenems types of drug reaction types of drug reaction Drug reactions vary greatly

The reoxidation of compounds with iodine containing molecules in the presence of O 2 through hydrogen peroxide (H 2 O 2 ) intermediates has been previously demonstrated 37

Free radicals often stem from chronic inflammation, autoimmune disorders, or exposure to pollutants

Storage Instructions Controlled room temperature (per investigational protocol) Protect from excessive moisture and heat No refrigeration needed for oral solid formulations Keep in original container until use Important Clinical Context Tesofensine has not been approved by the FDA for obesity treatment