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The other three drugs which failed in the experimental validation were atovaquone, icatibant and tioconazole, but showed promising results in other studies: atovaquone was previously shown to inhibit cellular respiration in breast cancer cells at a concentration of 5 M [61], to increase oxygenation of tumours [62] and platinum-mediated cell death due to oxidative stress

This mechanism has been linked with reduced fat cell size , increased insulin sensitivity , and improved overall metabolic efficiency

Renal involvement in toxic epidermal necrolysis

Hypoxia enhances proliferation and stemness of human adipose-derived mesenchymal stem cells