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Aged mice (12 months, roughly equivalent to middle age in humans) administered MOTS-c for four weeks showed improved physical performance, grip strength, and metabolic markers compared to controls

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HIF-1 is a master regulator of cellular adaptation to hypoxia, which translocates to the nuclei of brain capillary ECs cultured under hypoxic conditions and has been suggested as a potent therapeutic target in cerebral ischemia