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The RnB protocol has been found to be highly effective in reversing the symptoms of CFS (RnB protocol) Creatine supplementation has also proven to have some success in some individuals (Allen, 2012)

R3 is selected from the group consisting of a hydrogen atom and an R4-CO (acyl) group, wherein R4 is an alkyl (e.g., C 1 -C 20 ) or aryl (e.g., C 6 -C 9 ) group